Anti-human Latent TGF-β1 mAb (detection), biotin

Standard curve for human latent TGF-β1 in bead-based multiplex.

Anti-human Latent TGF-β1 mAb (detection), biotin

5334-6-100

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Anti-human Latent TGF-β1 mAb (capture), unconjugated

Intended use

This monoclonal antibody enables specific detection of human latent TGF-β1 mAb in bead-based multiplex assays. For research use only. Not for use in diagnostic procedures.

Serum/Plasma samples

Recommendation

Anti-human latent TGF-β1 mAb (detection) is recommended in combination with Anti-human latent TGF-β1 mAb (capture) (product code 5334-3) in bead-based multiplex.

Product details

Product	Anti-human Latent TGF-β1 mAb (detection), biotin
Application	Bead-based multiplex
Analyte	TGF-β1 (Latent TGF-β1)
Antibody	Anti-human Latent TGF-β1 mAb (detection)
Conjugate	Biotin
Clonality	Monoclonal
Reactivity	Human
Specificity	Native and recombinant latent Transforming Growth Factor-β1 (TGF-β1). The antibody binds to the human Latency Associated Protein (LAP), which is a part of the latent TGF-β1 complex.
Cross-reactivity	The antibody does not bind to human latent TGF-β2 or -β3.
Purification	Purified from in vitro cultures by protein G affinity chromatography.
Biotinylation	Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.
Concentration	0.5 mg/ml
Supplied in	PBS with 0.02% sodium azide. Sterile-filtered (0.2 µm).
Contents	Anti-human latent TGF-β1 mAb (detection), biotin. Supplied at 0.5 mg/ml in PBS with 0.02% sodium azide.

Shipping and Storage

Shipping	Shipped at ambient temperature.
Storage	Store product at 4-8°C.
Shelf life	At least 12 months from date of receipt.

Representative standard curve for human latent TGF-β1 in bead-based multiplex.

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TGF-β1 (Latent TGF-β1)

Analyte description	Transforming growth factor β1 (TGF-β1) is secreted by many cells and controls functions such as cell growth, cell differentiation, proliferation, and apoptosis. The cytokine TGF-β1 is an important regulator of immune functions. Specifically for T cells, TGF-β1 promotes the differentiation of regulatory T cells, preventing IL-1- and IL-2-dependent proliferation of activated T cells, the activation of helper T cells, and cytotoxic T cells. TGF-β1 is secreted in a latent, biologically inactive form, non-covalently linked with a latency associated protein (LAP).
Alternative names	Transforming growth factor β1, TGF-β1, TGF beta 1, latency associated peptide, LAP, CED, DPD1, IBDIMDE, TGF-beta1, TGFB, TGFbeta
Cell type	T cell, Th1, Th17, Treg, Tfh, Monocyte/MΦ
Gene ID	7040