Anti-human IL-17A mAb (capture), unconjugated
Anti-human IL-17A mAb (capture), unconjugated
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Complementary products
Complementary products
Representative standard curve for human IL-17A in bead-based multiplex
Selecting the appropriate mAbs is key to effectively detecting human IL-17A/F. This mAb guide describes which combination of our mAbs should be used in ELISA and ELISpot assays.
Application guide: ELISA
Our human IL-17A/F ELISA kits can be used to detect the important cytokine in solution, whether it be in serum, cell culture media, or plasma samples.
Coating mAb: MT504, unconjugated
Detection mAb: MTF411, biotin
Application guide: ELISpot
Our human IL-17A/F ELISpot kits can be used to detect the important cytokine directly upon secretion by responding cells.
Coating mAb: MTF411, unconjugated
Detection mAb: MT504, biotin
IL-17A
| Analyte description | Interleukin 17A (IL-17A) is a potent proinflammatory cytokine produced by activated Th17 (T helper 17) cells and certain cells belonging to the innate immune system. In mice, IL-17 has also been shown to be produced by activated CD8 T cells and γδ T cells. Th17 cells play an important role in autoimmune diseases and protection against bacteria and fungi. IL-17A acts on a broad range of cell types to induce the expression of cytokines, chemokines, and metalloproteinases. As a result, secretion of IL-17A promotes inflammatory responses, which leads to the recruitment of neutrophils, enhancement of antibody production, and activation of T cells. Increased expression of IL-17A is seen in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. It is also associated with asthma, psoriasis, cancer, and transplant rejection. |
| Alternative names | Interleukin 17A, IL-17A, IL17A, CTLA-8, CTLA8, IL-17, IL17, ILA17 |
| Cell type | Th17 |
| Gene ID | 3605 |