Anti-human IL-12/-23 (p40) mAb (MT3279H), azide free

3450-0N-500

Publications: 1

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Intended use

This monoclonal antibody enables neutralization of human IL-12/-23 bioactivity.

Serum/Plasma samples

Recommendation

It is recommended to establish the optimal antibody concentration for the assay system used.

Product details

Product	Anti-human IL-12/-23 (p40) mAb (MT3279H), azide free
Application	Neutralization
Analyte	IL-12/-23 (p40)
Antibody	MT3279H
Conjugate	Unconjugated
Clonality	Monoclonal
Immunogen	Recombinant human IL-23
Host	Mouse
Isotype	IgG2b
Reactivity	Human
Specificity	Native and recombinant p40 subunit of human IL-12 and IL-23
Purification	Purified from in vitro cultures by protein G affinity chromatography.
Concentration	1 mg/ml
Supplied in	PBS, free of preservatives. Sterile-filtered (0.2 µm).
Contents	Monoclonal antibody MT3279H, unconjugated. Supplied at 1 mg/ml in PBS, free of preservatives.

Shipping and Storage

Shipping	Shipped at ambient temperature.
Storage	Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/thawing.
Shelf life	At least 12 months from date of receipt.

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IL-12/-23 (p40)

Analyte description	Interleukin 12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. IL-12 is produced by antigen-presenting cells, specifically dendritic cells, and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing the proliferation and cytotoxicity of NK and T cells. Interleukin-23 (IL-23) is a disulfide-linked heterodimer that consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells, and IL-23 is responsible for Th17 expansion and stabilization. Since both IL-12 and IL-23 heterodimers comprise the p40 subunit, capture immunoassays based on antibodies to p40 will detect both cytokines. Such assays can also detect p40 monomers and dimers.
Alternative names	Interleukin 12, IL-12, IL12, IL12A, IL12B, CLMF, IL-12A, NFSK, NKSF1, P35, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2
Cell type	Monocyte/MΦ, mDC
Gene ID	3592, 3593