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Non-Human Primate Cross-reactivity

Mabtech offers a broad range of ELISpot kits in different formats for the detection of cytokines and other immunological effector molecules in samples from non-human primates (NHP).

The systems reactive with NHPs are either based on cross-reactive human kits or specifically developed monkey kits (NHP).

Cross-reactivity verification tests have been performed in ELISpot and/or ELISA by Mabtech and/or by others. Evaluations of assays with less solid evidence of cross-reactivity are shown as symbols within parentheses.

 

  Rhesus Macaque Cynomolgus Macaque Pig-tailed Macaque Baboon* Sooty Mangabey African Green Monkey Night Monkey* Common Marmoset Squirrel Monkey
ASSAY Old world New world
  Rhesus Macaque Cynomolgus Macaque Pig-tailed Macaque Baboon* Sooty Mangabey Afr. Green Monkey Aotus* Common Marmoset Squirrel Monkey
Assay Old world New world
ApoA1           
ApoB              
ApoE (NHP)              
ApoE            
ApoH          
GM-CSF ( ) ( )      
Granzyme A                
Granzyme B          
IFN-α2                
IFN-α pan       ( )      
IFN-γ (NHP)
IFN-γ ( )
IgA (NHP)              
IgA              
IgG              
IgM              
Insulin            
IL-2 (NHP)
IL-4 ( ) ( ) ( ) ( )
IL-5 ( ) ( ) ( )  
IL-6 ( ) ( )   ( )  
IL-8 (NHP)                
IL-8                
IL-10              
IL-12/-23 (p40)            
IL-12 (p70)                
IL-13 ( ) ( ) ( )    
IL-17A (NHP) ( ) ( )      
IL-17A          
IL-21            
IL-22                
IL-23          
IL-31                
Perforin ( )      
TGF-β1 (latent)              
  Rhesus Macaque Cynomolgus Macaque Pig-tailed Macaque Baboon* Sooty Mangabey Afr. Green Monkey Aotus* Common Marmoset Squirrel Monkey
                   
SINGLE mAbs Old world New world
SINGLE mAbs                  
Cell stimulation Old world New world
Cell stimulation                  
CD3, mAb CD3-1              
CD3, mAb CD3-2              
CD28, mAb CD28-A              
Flow cytometry Old world New world
Flow cytometry                  
Granzyme B, mAb GB11                
IFN-γ, mAb 1-D1K ( ) ( ) ( ) ( ) ( ) ( )
IL-2 mAb MT8G10 ( ) ( ) ( ) ( )   ( ) ( ) ( )
IL-17A mAb MT504                
Perforin mAb Pf-344          
Ig reagents Old world New world
Ig reagents                  
IgG1 mAb MT1939              
IgG2 mAb H6200              
IgG3 mAb MTG34              
IgG4 mAb MTG42              
Western blot Old world New world
Western blot                  
IFN-γ, mAb MT111W ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( )

Symbol keys:

Cross-reactivity

Verified by Mabtech and/or by others. Tests performed in ELISpot and/or ELISA.

  • good
  • poor
  • no
Indications of Cross-reactivity

Based on reports from others or by analysis using recombinant proteins.

  • ( ) good
  • ( ) poor
  • ( ) no
Monkey kits

Specifically developed monkey kits are marked with (NHP).

Blank boxes

Represent cross-reactivities not evaluated.

* Comprises several species. Cross-reactivity may have to be verified on a species basis.