Anti-human CD8 mAb (CD8-1), azide free

Anti-human CD8 mAb (CD8-1), azide free

3607-1-1000

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Content

Monoclonal antibody CD8-1, unconjugated. Supplied at 1 mg/ml in sterile filtered PBS, free of preservatives.

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Product specifications

Intended use

This monoclonal antibody enables specific detection of human CD8 positive cells in immunoassays such as flow cytometry and immunohistochemistry.

Serum/Plasma samples

Recommendation

It is recommended to establish the optimal antibody concentration for the assay system used.

Product details

ProductAnti-human CD8 mAb (CD8-1), azide free
ApplicationImmunocytochemistry
AnalyteCD8
AntibodyCD8-1
ConjugateUnconjugated
ClonalityMonoclonal
ImmunogenStimulated human leukocytes
HostMouse
IsotypeIgG1
ReactivityHuman
SpecificityHuman CD8
PurificationPurified from in vitro cultures by protein G affinity chromatography.
Concentration1 mg/ml
Supplied inPBS, free of preservatives. Sterile-filtered (0.2 µm).
ContentsMonoclonal antibody CD8-1, unconjugated. Supplied at 1 mg/ml in sterile filtered PBS, free of preservatives.

Shipping and Storage

ShippingShipped at ambient temperature.
StorageStore product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/thawing.
Shelf lifeAt least 18 months from date of receipt.
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CD8

Analyte description

CD8 (cluster of differentiation 8) is predominantly expressed on the surface of cytotoxic T cells but is also present on natural killer cells, cortical thymocytes, and dendritic cells. CD8 functions as a co-receptor for MHC class I molecules. When T cells interact with antigen-presenting cells, the CD8 heterodimer binds to a conserved portion of MHC class I. CD8 T cells play a critical role in fighting intracellular pathogens, including viruses and bacteria, as well as monitoring tumors. When a CD8 T cell recognizes its antigen and becomes activated, it has three central mechanisms to kill infected or malignant cells. The first is the secretion of cytokines (primarily TNF-α and IFN-γ), the second is the production and release of cytotoxic granules, and the third is the destruction of infected cells via Fas/FasL interactions. 

Alternative namesCluster of differentiation 8, CD8, Leu2, p32
Cell typeTc
Gene ID925