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Official news and announcements about our company and our products.

Allogeneic dendritic cells as off-the-shelf immune boosters

Sweden-based Laurell et al (2017) think outside the box when they utilize allogeneic instead of autologous dendritic cells (DC) to enhance anti-tumor responses. These activated DCs are not used for antigen-presentation, but when injected into the tumor site they start a local inflammation and secrete pro-inflammatory cytokines and chemokines that attract and activate bystander autologous DCs. The autologous DCs will in turn engulf tumor debris, migrate to the draining lymph node and present tumor antigens to T cells.

Thus, this strategy uses the patient’s own tumor as antigen source in situ (double italics on that one!), circumventing the ordeal with producing tumor-antigen presenting autologous DCs in vitro. In addition, since there’s no MHC-restriction to account for, the allogenic DCs can act as an off-the-shelf immunogenic adjuvant for anti-tumor responses. Very cool.

Oh yeah, and of course the authors used Mabtech’s IFN-gamma ELISpotPLUS kit to evaluate tumor specific responses after putting their DC-based immunotherapy apporach to the test in patients with renal cell carcinoma.

Wednesday, June 28, 2017

B cell assays for pig samples

We have a totally new system to detect pig IgG. Choose between measuring antibody concentration with an ELISA, or enumerating antibody producing plasma cells using an ELISpot kit. The detection antibody for ELISA is available directly conjugated to HRP.

Please find all new kits and regents in the web shop.

Wednesday, June 28, 2017

iPSC-derived hepatocytes for drug identification and to study cellular pathophysiology

Cayo et al. have made an impressive work using new techniques such as iPSCs and humanized mice, to show that cardiac glycosides reduces hepatocyte production of apoB. They use apoB ELISA from Mabtech to analyze apoB secreted from iPSC-derived hepatocytes, and apoB in serum of avatar mice. They have also used the anti-apoB LDL17/20 for immunoprecipitation and Western Blot. Their article was published in April 2017 in the renowned journal Cell Stem Cell, and in the same edition, two other publications, Pashos et al. and Warren et al., are also analyzing secreted apoB from iPSC-derived hepatocytes using Mabtech’s apoB ELISA.

Liu et al. and Yang et al. are two additional recent papers studying inherited disorders with iPSC-derived hepatocytes, and like in the other articles, the authors are also using Mabtech’s apoB ELISA.

Friday, June 16, 2017

Use of R848 and IL-2 to stimulate memory B cells

In 2013, Jahnmatz, M et al published a newly developed protocol for polyclonal activation of human memory B cells. The authors showed the superior functionality of stimulating B cells using the TLR7/8-agonist R848 and IL-2 compared to the other stimulation protocols used at the time. Since then, we include R848 and IL-2 in all of our human immunoglobulin ELISpot and FluoroSpot kits.

The article is now one of the most highly cited papers in Journal of Immunological Methods.

Thursday, June 15, 2017

Characterization of Wilms’ tumor specific T cells with FluoroSpot

Danielzik et al. utilized Mabtech’s IFN-γ/Granzyme B FluroSpot kit to detect among others rare, specific, and double secreting T cells against Wilms’ tumor. The study honors high sensitivity, small sample size and the possibility to detect three different cell times in one FluoroSpot assay!

Tuesday, June 13, 2017

Mouse IgM Product Update

We are replacing our mouse IgM system with a newly developed monoclonal antibody pair from immunized rats. The improved antibodies are available in ELISA as well as ELISpot kits. In addition, we are for the first time introducing an ELISA with the detection antibody directly conjugated to enzyme HRP. Please find the new products in our web shop.

Thursday, June 8, 2017

IL-8 secretion in cattle after BoHV-4 infection

Premiere for our bovine IL-8 ELISA kit in the Reference-section. The study of Chanrot et al. demonstrates the susceptibility of bovine endometrial epithelial cells to bovine herpes virus 4 (BoHV-4), leading to increased IL-8 secretion. BoHV-4 is transmitted through breeding and is associated with abortion and chronic infertility in cows.

Tuesday, May 30, 2017

CMV monitoring with IFN-gamma ELISpot

Barabas et al show that an ELISpot assay with Mabtech’s anti-human IFNg antibodies is a sound choice for CMV monitoring after transplantation.

In addition, the assay proved to have low intra-assay, inter-assay, inter-operator and inter-site variability, and high linearity, sensitivity and specificity.

Wednesday, May 24, 2017

Launch of Mouse IgE ELISpot

Mouse IgE ELISpot

We are pleased to launch ELISpotBASIC for detection of mouse IgE secreting cells. ELISpot for specific detection of mouse IgEa (allotype a) secreting cells are also available.

Please visit the web shop for products

Wednesday, April 5, 2017

Launch of Human IL-1ß ELISAPRO

Human IL-1ß ELISAPRO kits for sensitive quantification of IL-1ß in serum, plasma and cell culture supernatants are now available in the web shop.

Our ELISAPRO kits are carefully validated complete kits including pre-coated strip-plates, reagents and buffers.

View the IL-1ß ELISAPRO kits in the web shop.

Wednesday, March 15, 2017