Alzheimer’s research with apolipoprotein ELISA

Two recent studies emphasized the benefit of using Mabtech’s ELISA kits for quantification of apolipoproteins. Slot et al.  (Neurobiology of aging, 2019) suggested that the apolipoproteins (Apo) E and ApoJ (clusterin) play a role in the cascade leading to Alzheimer’s independently of amyloid beta (Aβ) deposition. The levels of apoE, ApoJ, and, apoA1 were quantified in CSF using sensitive ELISAs from Mabtech.

In another Alzheimer’s study, ApoJ levels were also determined: Fernández de Retana et al. (Alzheimers Res Ther, 2019) nicely demonstrated that an increase in circulating human rApoJ reduced insoluble Aβ and cerebral β amyloidosis in an experimental mouse model. Thus, the authors showed that apoJ have a potential protective role in Alzheimer’s.

Apolipoproteins regulate lipid homeostasis in the brain and are involved in the development of Alzheimer’s in an Aβ dependent or independent manner. Both of these two papers stress the need for more studies on apolipoproteins in the context of Alzheimer’s.