What is TGF-β1 (Latent TGF-β1)?

Transforming growth factor β1 (TGF-β1) is secreted by many cells and controls functions such as cell growth, cell differentiation, proliferation, and apoptosis. The cytokine TGF-β1 is an important regulator of immune functions. Specifically for T cells, TGF-β1 promotes the differentiation of regulatory T cells, preventing IL-1- and IL-2-dependent proliferation of activated T cells, the activation of helper T cells, and cytotoxic T cells. TGF-β1 is secreted in a latent, biologically inactive form, non-covalently linked with a latency associated protein (LAP). 

Alternative analyte names:Transforming growth factor β1, TGF-β1, TGF beta 1, latency associated peptide, LAP
Cell types:T cell, Th1, Treg, Tfh, Monocyte/MΦ, Th17
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