What is IL-21?

Interleukin 21 (IL-21) is primarily secreted by CD4 T cells (particularly follicular T cells and Th17) and is an important regulator of immune responses. For Th17 cells, IL-21 is an autocrine regulator sustaining Th17 development. IL-21 also regulates the development of other T cells as well as B cells, NK cells, and dendritic cells. Areas of particular interest for research on IL-21 include autoimmune and inflammatory diseases, cancer research, and basic studies on, e.g., B cells and T cells, especially on Th17 cells.

Alternative analyte names:Interleukin 21, IL-21, IL21
Cell types:T cell, Tc, Tfh, Th17
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