What is Granzyme A?

Granzyme A is a serine protease packed together with e.g., granzyme B and perforin in cytoplasmic granules within cytotoxic T cells and NK cells. Release of the granule content is crucial for the elimination of infected or transformed cells. Perforin facilitates the delivery of granzymes, and cells resistant to the cytotoxic action of granzyme B may be sensitive to granzyme A and vice versa. Thus, the content of the granules will act in concert to induce target cell death by apoptosis.

Alternative analyte names:Granzyme A, GzmA, GrA, GrzA
Cell types:T cell, Tc, Th1, NK cell, Th17
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