Interleukin-4 (IL-4) is produced by activated T cells, especially differentiated CD4+ TH2-type cells, and stimulated mast cells and basophils. The most important effects of IL-4 are the regulation of helper T cell differentiation to the TH2 type and the regulation of IgE and IgG4 production by B cells.
Cross-reactivity has been tested and confirmed with certain non-human primate species. Please consult this comprehensive table for cross-reactivity information.
