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Mabtech Webshop > ELISpot > Monkey > Interleukin-17A
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Interleukin-17A
IL-17A is mainly produced by a recently discovered subset of CD4+ effector T helper cells (Th17) (adaptive immune system), but other cells belonging to the innate immune system can also produce IL-17A. IL-17A has proinflammatory properties and acts on a broad range of cell types to induce expression of cytokines, chemokines and metalloproteinases. IL-17A is also a key cytokine for the recruitment, activation, and migration of neutrophiles. IL-17A has also been reported to be a factor that contributes to the formation of germinal centers. Th17 cells are involved in the protection against certain bacteria and fungi that are not cleared by Th1 or Th2 cells. In addition Th17 cells are potent inducers of tissue inflammation and have been associated with the pathogenesis of autoimmune diseases, inflammatory conditions and cancer.
Cross-reactivity has been assessed and confirmed with Rhesus and Cynomolgus macaques.
For cross-reactivity with other NHP species, please consult this comprehensive table.
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