Human IL-12/-23 (p40) ELISpot PLUS kit (HRP)
Interleukin-12 (IL-12) is, when biologically active, a heterodimer (p70) consisting of two covalently linked subunits, p35 and p40. IL-12 is produced by antigen-presenting cells, specifically dendritic cells and macrophages. IL-12 is a proinflammatory cytokine that promotes Th1-type responses by inducing IFN-γ production and enhancing proliferation and cytotoxicity of NK and T cells.
Interleukin-23 (IL-23) is a disulfide-linked heterodimer which consists of a unique p19 subunit and the p40 subunit of IL-12. IL-23 is a proinflammatory cytokine, which is produced by macrophages and dendritic cells upon infections with certain pathogens. The IL-23 receptor is expressed on Th17 cells and IL-23 is responsible for Th17 expansion and stabilization.
Since both IL-12 and IL-23 heterodimers comprise the p40 subunit, capture immunoassays based on antibodies to p40 will detect both cytokines. Such assays can also detect p40 monomers and dimers.
Cross-reactivity has been assessed and confirmed with certain non-human primate species.
Please consult this comprehensive table for information about cross-reactivities with non-human primates.
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| Human IL-12/-23 (p40) ELISpot PLUS kit incl. plates and substrate |
| Code |
Description |
Quantity |
Price |
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| 3450-2HW-Plus |
Human IL-12/-23 (p40) ELISpot PLUS kit (HRP) |
4 x 96 |
5 100 SEK
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| Format: | Kit containing 4 plates, capture and detection antibodies, Streptavidin-HRP and TMB substrate | | Application: | ELISpot | | Reactivity: | Reacts with Human, cross reacts with Rhesus and Cynomolgus macaques. Please consult this comprehensive table for reactivities with other non-human primates. |
ELISpot PLUS kit for the detection of human or monkey IL-12 and IL-23. This complete kit contains ELISpot plates with PVDF membrane, monoclonal capture antibody, monocl. biotin. detection antibody, Streptavidin-HRP and TMB substrate.
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